Radiological findings of long bones in wild-type (WT) and <i>Gli1</i>^+/− mice.

<p>(<b>A</b>) Three-dimensional micro-computed tomography (3D-micro-CT) images of the distal femurs of representative 8-week-old WT and <i>Gli1</i>^+/− male mice. Sagittal sections, transverse sections, and 3D reconstruction images of the primary spongiosa are shown for each genotype. Bar, 1 mm. (<b>B</b>) Histomorphometric analyses of 3D-micro-CT data. BMD, bone mineral density; BV/TV, bone volume per tissue volume; Tb.Th, trabecular thickness; Tb.N trabecular number parameters. Data are means ± SDs of eight male mice per genotype. *p<0.05 vs. WT.