Growth factors potentiate LPA chemotaxis.
- Andrew J. Muinonen-Martin (235328)
- Olivia Susanto (644354)
- Qifeng Zhang (116382)
- Elizabeth Smethurst (644355)
- William J. Faller (644356)
- Douwe M. Veltman (220981)
- Gabriela Kalna (192504)
- Colin Lindsay (644357)
- Dorothy C. Bennett (234520)
- Owen J. Sansom (192366)
- Robert Herd (644358)
- Robert Jones (270787)
- Laura M. Machesky (175567)
- Michael J. O. Wakelam (116384)
- David A. Knecht (231111)
- Robert H. Insall (220984)
Publication date
October 2014
DOIAbstract
<p>(A) Growth factors enhance cells' response to LPA gradients. Figure shows plots of the WM239A paths chemotaxing in gradients of LPA, LPA+EGF+PDGF, and conflicting gradients of LPA versus EGF+PDGF. (B) Chemotactic indices of cells in (A) and other conditions. Growth factor gradients if anything increase the efficiency of LPA chemotaxis, even when applied in a gradient in the opposite direction. Bars show SEM.</p
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