Effect of preventive treatment with <i>Sm</i>SWP on inflammatory parameters.

<p>Effect on clinical disease score (<b>A</b>), body weight (<b>B</b>), colonoscopic score (<b>C</b>), macroscopic inflammation score (<b>D</b>), colon length (<b>E</b>), microscopic inflammation score (<b>F</b>) and MPO activity (<b>G</b>). Data are presented as mean ± SEM. Generalized Estimations Equations was used to analyze the evolution of the body weight, the clinical disease score and colonoscopic score over time and an LSD post-hoc analysis was applied. One-way ANOVA with LSD post-hoc test was used to compare the results of macroscopic and microscopic scores, colon length and MPO activity between groups. ^#: <i>P</i>≤0.05, significantly different from CONTROL group; *: <i>P</i>≤0.05, significant difference between the COLITIS and COLITIS+prev<i>Sm</i>SWP groups; ^§: <i>P</i>≤0.05, significant increase in score over time within groups; “n” representing the number of mice. Abbreviations: LSD: least significant difference; MPO: myeloperoxidase; prev: preventive; SEM: standard error of the mean; <i>Sm</i>SWP: <i>Schistosoma mansoni</i> soluble worm proteins.