Kainate-induced cell death susceptibility is reduced in the FVB.B6-<i>Sicd1/Sicd2</i> double congenic strain.

<p>Susceptibility to kainate-induced cell death in FVB-like littermates, FVB.B6-<i>Sicd1</i> congenic strain, FVB.B6-<i>Sicd2</i> congenic strain, and FVB.B6-<i>Sicd1/Sicd2</i> double congenic strain at 7 days following systemic administration of kainic acid. Low-magnification photomicrographs of cresyl violet-stained horizontal sections of the hippocampus illustrating surviving cells throughout the hippocampus (A,F,K, and Q). High-magnification cresyl violet staining of area CA3 (B, G, L, andR) and the dentate hilus (C, H, M, and S) in FVB-like littermates (B,C), FVB.B6-<i>Sicd1</i> (G,H), FVB.B6-<i>Sicd2</i> (L,M), and FVB.B6-<i>Sicd1/Sicd2</i> (R,S) and high-magnification Fluoro-Jade staining of area CA3 and the dentate hilus in FVB (D,E), FVB.B6-<i>Sicd1</i> (I,J), FVB.B6-<i>Sicd2</i> (O,P), and FVB.B6-<i>Sicd1/Sicd2</i> (T,U). Note that a reduction in the extent of cell death is observed throughout area CA3 in all congenic strains (G,I,L,O,R,T) as compared to FVB-like littermates (B,D). A dramatic reduction in the extent of cell death was observed in the dentate hilus only in FVB.B6-<i>Sicd1/Sicd2</i> double congenic mice (S,U) as compared to FVB-like littermates (C,E). CA1 and CA3, hippocampal subfields; H, dentate hilus. Scale bars: 750 µm (A,F,K, and Q) and 100 µm (B,C,D,E,G,H,I,J,L,M,O,P,R,S,T, and U).