Anti-proliferative activity (IC50 values) of the novel thiosemicarbazones in comparison to DFO and Dp44mT in several tumor cell-types and normal human dermal fibroblast (NHDF) cells.

Novel thiosemicarbazone iron chelators induce up-regulation and phosphorylation of the metastasis suppressor N-myc down-stream regulated gene 1: A new strategy for the treatment of pancreatic cancer

Kovacevic, Zaklina
Chikhani, Sherin
Lovejoy, David B
Richardson, Des R

January 2011

Pancreatic cancer is an aggressive neoplasm, with a mortality rate close to 100%. The most successfu...

Identificazione dei targets cellulari e del meccanismo d'azione molecolare di complessi metallici di nuova sintesi

Montalbano, Serena

March 2019

The end goal of this project is the study of the biological activity of newly synthesized compounds,...

Synthesis Of Thiophene-thiosemicarbazone Derivatives And Evaluation Of Their In Vitro And In Vivo Antitumor Activities

de Oliveira
Jamerson Ferreira
Anekecia Lauro
Debora Barbosa
Cezar Augusto
Julia Furtado
Amelia Galdino
Ricardo Olimpio
Jorge Luiz
Ana Lucia
Joao Ernesto
Maria do Carmo

June 2016

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)A series of thiophene-2-thiosemi...

Exploring the anti-cancer activity of novel thiosemicarbazones generated through the combination of retro-fragments: dissection of critical structure-activity relationships.

Maciej Serda
Danuta S Kalinowski
Nathalie Rasko
Eliška Potůčková
Anna Mrozek-Wilczkiewicz
Robert Musiol
Jan G Małecki
Mieczysław Sajewicz
Alicja Ratuszna
Angelika Muchowicz
Jakub Gołąb
Tomáš Simůnek
Des R Richardson
Jaroslaw Polanski

Thiosemicarbazones (TSCs) are an interesting class of ligands that show a diverse range of biologica...

Exploring the Anti-Cancer Activity of Novel Thiosemicarbazones Generated through the Combination of Retro-Fragments: Dissection of Critical Structure-Activity Relationships

Maciej Serda (645761)
Danuta S. Kalinowski (525221)
Nathalie Rasko (645762)
Eliška Potůčková (5660962)
Anna Mrozek-Wilczkiewicz (645763)
Robert Musiol (645764)
Jan G. Małecki (645765)
Mieczysław Sajewicz (645766)
Alicja Ratuszna (645767)
Angelika Muchowicz (645768)
Jakub Gołąb (645769)
Tomáš Šimůnek (2568280)
Des R. Richardson (141026)
Jaroslaw Polanski (645770)

October 2014

<div>Thiosemicarbazones (TSCs) are an interesting class of ligands that show a diverse range of b...

Novel thiosemicarbazone derivative 17B interferes with the cell cycle progression and induce apoptosis through modulating downstream signaling pathways

Bozgeyik, Esra
Taşdemir Kahraman, Demet
Arman, Kaifee
Bozgeyik, İbrahim
Karaküçük İyidoğan, Ayşegül
Çakmak, Ecir Ali

January 2020

Thiosemicarbazones (TSCs) are interesting group of chemical compounds that received significant leve...

Anti-proliferative activity (IC50 values) of the novel Triapine analogs compared to Triapine in several tumor cell-types and normal human dermal fibroblast (NHDF) cells.

Marta Rejmund (5100413)
Anna Mrozek-Wilczkiewicz (645763)
Katarzyna Malarz (829453)
Monika Pyrkosz-Bulska (5100410)
Kamila Gajcy (5100416)
Mieczyslaw Sajewicz (5100419)
Robert Musiol (645764)
Jaroslaw Polanski (645770)

April 2018

Individual IC50 values IC50 < 1μM, IC50 1–10 μM, IC50 > 10 μM are coded by red, yellow and grey, ...

The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms

Zhu-Ling Guo
Des R. Richardson
Danuta S. Kalinowski
Zaklina Kovacevic
Kian Cheng Tan-Un
Godfrey Chi-Fung Chan

September 2016

Abstract Background Neuroblastoma is a relatively common and highly belligerent childhood tumor with...

Effect of Thiosemicarbazone Complexes as Anticancer Agents on In-Vitro Cancer Cell-Lines

Methvin, Carlynne
Nesbitt, Abigail
Foster, Nick

May 2017

Thiosemicarbazone metal complexes were synthesized in the lab and their effects as anticancer agents...

Thiosemicarbazone Iron Chelator: Evaluation of the anti-cancer activity and mechanisms of action

Yu, W.
Yu, Yu
Richardson, D.

January 2011

Previous studies demonstrated that thiosemicarbazone iron chelator possessed potent and selective an...

Novel Thiosemicarbazones Regulate the Signal Transducer and Activator of Transcription 3 (STAT3) Pathway: Inhibition of Constitutive and Interleukin 6–Induced Activation by Iron Depletion

Goldie Y. L. Lui
Zaklina Kovacevic
Sharleen V. Menezes
Danuta S. Kalinowski
Angelica M. Merlot
Sumit Sahni
Des R. Richardson

January 2014

Pharmacologic manipulation of metal pools in tumor cells is a promising strategy for cancer treatmen...

COMBATTING CHALLENGING ASPECTS OF CANCER WITH THIOSEMICARBAZONES

Sharma, Neetu
Pathak, Dharam Pal

August 2016

Cancer claims the second largest number of deaths across the globe every year. With the new addition...

Evaluation of Potent Isoquinoline-Based Thiosemicarbazone Antiproliferatives Against Solid Tumor Models

Daniel Sun (6495698)
Soumya Poddar (6495728)
Roy D. Pan (6491381)
Juno Van Valkenburgh (6495686)
Ethan Rosser (6495662)
Evan Abt (6495692)
Vincent Lok (6497174)
Joseph Capri (6499729)
Selena Hernandez (6495677)
Janet Song (6495788)
Joanna Li (6495734)
Laurent Vergnes (6499730)
Anthony Cabebe (6498977)
Wesley Armstrong (6495674)
Sheba Plamthottam (6495671)
Dalton Steele (6499732)
Corey Osto (6499735)
Andreea Stuparu (6495668)
Thuc Le (6495683)
Karen Reue (6499736)
Robert Damoiseaux (6499738)
Johanes Czernin (6495737)
Michael Jung (6498152)
Caius Radu (6495740)

March 2019

The lead compound, an ⍺-N-heterocyclic carboxaldehyde thiosemicarbazone HCT-13, was highly potent ag...

N4-aryl substituted thiosemicarbazones derived from 1-indanones as potential anti-tumor agents for breast cancer treatment

Solimo, Aldana
Soraires Santacruz, Maria Cristina
Loaiza Perez, Andrea Irene
Bal, Elisa Dora
Finkielsztein, Liliana Mónica
Callero, Mariana Alejandra

June 2018

Breast cancer is the first cause of cancer death in women. Many patients are resistant to current th...

Bp44mT: An orally active iron chelator of the thiosemicarbazone class with potent anti-tumour efficacy

Yu, Yu
Rahmanto, Y.
Richardson, D.

January 2012

Background and Purpose: Our previous studies demonstrated that a thiosemicarbazone iron chelator (di...

Novel thiosemicarbazone iron chelators induce up-regulation and phosphorylation of the metastasis suppressor N-myc down-stream regulated gene 1: A new strategy for the treatment of pancreatic cancer

Kovacevic, Zaklina
Chikhani, Sherin
Lovejoy, David B
Richardson, Des R

January 2011

Pancreatic cancer is an aggressive neoplasm, with a mortality rate close to 100%. The most successfu...

Identificazione dei targets cellulari e del meccanismo d'azione molecolare di complessi metallici di nuova sintesi

Montalbano, Serena

March 2019

The end goal of this project is the study of the biological activity of newly synthesized compounds,...

Synthesis Of Thiophene-thiosemicarbazone Derivatives And Evaluation Of Their In Vitro And In Vivo Antitumor Activities

de Oliveira
Jamerson Ferreira
Anekecia Lauro
Debora Barbosa
Cezar Augusto
Julia Furtado
Amelia Galdino
Ricardo Olimpio
Jorge Luiz
Ana Lucia
Joao Ernesto
Maria do Carmo

June 2016

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)A series of thiophene-2-thiosemi...

Exploring the anti-cancer activity of novel thiosemicarbazones generated through the combination of retro-fragments: dissection of critical structure-activity relationships.

Maciej Serda
Danuta S Kalinowski
Nathalie Rasko
Eliška Potůčková
Anna Mrozek-Wilczkiewicz
Robert Musiol
Jan G Małecki
Mieczysław Sajewicz
Alicja Ratuszna
Angelika Muchowicz
Jakub Gołąb
Tomáš Simůnek
Des R Richardson
Jaroslaw Polanski

Thiosemicarbazones (TSCs) are an interesting class of ligands that show a diverse range of biologica...

Exploring the Anti-Cancer Activity of Novel Thiosemicarbazones Generated through the Combination of Retro-Fragments: Dissection of Critical Structure-Activity Relationships

Maciej Serda (645761)
Danuta S. Kalinowski (525221)
Nathalie Rasko (645762)
Eliška Potůčková (5660962)
Anna Mrozek-Wilczkiewicz (645763)
Robert Musiol (645764)
Jan G. Małecki (645765)
Mieczysław Sajewicz (645766)
Alicja Ratuszna (645767)
Angelika Muchowicz (645768)
Jakub Gołąb (645769)
Tomáš Šimůnek (2568280)
Des R. Richardson (141026)
Jaroslaw Polanski (645770)

October 2014

<div>Thiosemicarbazones (TSCs) are an interesting class of ligands that show a diverse range of b...

Novel thiosemicarbazone derivative 17B interferes with the cell cycle progression and induce apoptosis through modulating downstream signaling pathways

Bozgeyik, Esra
Taşdemir Kahraman, Demet
Arman, Kaifee
Bozgeyik, İbrahim
Karaküçük İyidoğan, Ayşegül
Çakmak, Ecir Ali

January 2020

Thiosemicarbazones (TSCs) are interesting group of chemical compounds that received significant leve...

Anti-proliferative activity (IC50 values) of the novel Triapine analogs compared to Triapine in several tumor cell-types and normal human dermal fibroblast (NHDF) cells.

Marta Rejmund (5100413)
Anna Mrozek-Wilczkiewicz (645763)
Katarzyna Malarz (829453)
Monika Pyrkosz-Bulska (5100410)
Kamila Gajcy (5100416)
Mieczyslaw Sajewicz (5100419)
Robert Musiol (645764)
Jaroslaw Polanski (645770)

April 2018

Individual IC50 values IC50 < 1μM, IC50 1–10 μM, IC50 > 10 μM are coded by red, yellow and grey, ...

The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms

Zhu-Ling Guo
Des R. Richardson
Danuta S. Kalinowski
Zaklina Kovacevic
Kian Cheng Tan-Un
Godfrey Chi-Fung Chan

September 2016

Abstract Background Neuroblastoma is a relatively common and highly belligerent childhood tumor with...

Effect of Thiosemicarbazone Complexes as Anticancer Agents on In-Vitro Cancer Cell-Lines

Methvin, Carlynne
Nesbitt, Abigail
Foster, Nick

May 2017

Thiosemicarbazone metal complexes were synthesized in the lab and their effects as anticancer agents...

Thiosemicarbazone Iron Chelator: Evaluation of the anti-cancer activity and mechanisms of action

Yu, W.
Yu, Yu
Richardson, D.

January 2011

Previous studies demonstrated that thiosemicarbazone iron chelator possessed potent and selective an...

Novel Thiosemicarbazones Regulate the Signal Transducer and Activator of Transcription 3 (STAT3) Pathway: Inhibition of Constitutive and Interleukin 6–Induced Activation by Iron Depletion

Goldie Y. L. Lui
Zaklina Kovacevic
Sharleen V. Menezes
Danuta S. Kalinowski
Angelica M. Merlot
Sumit Sahni
Des R. Richardson

January 2014

Pharmacologic manipulation of metal pools in tumor cells is a promising strategy for cancer treatmen...

COMBATTING CHALLENGING ASPECTS OF CANCER WITH THIOSEMICARBAZONES

Sharma, Neetu
Pathak, Dharam Pal

August 2016

Cancer claims the second largest number of deaths across the globe every year. With the new addition...

Evaluation of Potent Isoquinoline-Based Thiosemicarbazone Antiproliferatives Against Solid Tumor Models

Daniel Sun (6495698)
Soumya Poddar (6495728)
Roy D. Pan (6491381)
Juno Van Valkenburgh (6495686)
Ethan Rosser (6495662)
Evan Abt (6495692)
Vincent Lok (6497174)
Joseph Capri (6499729)
Selena Hernandez (6495677)
Janet Song (6495788)
Joanna Li (6495734)
Laurent Vergnes (6499730)
Anthony Cabebe (6498977)
Wesley Armstrong (6495674)
Sheba Plamthottam (6495671)
Dalton Steele (6499732)
Corey Osto (6499735)
Andreea Stuparu (6495668)
Thuc Le (6495683)
Karen Reue (6499736)
Robert Damoiseaux (6499738)
Johanes Czernin (6495737)
Michael Jung (6498152)
Caius Radu (6495740)

March 2019

The lead compound, an ⍺-N-heterocyclic carboxaldehyde thiosemicarbazone HCT-13, was highly potent ag...

N4-aryl substituted thiosemicarbazones derived from 1-indanones as potential anti-tumor agents for breast cancer treatment

Solimo, Aldana
Soraires Santacruz, Maria Cristina
Loaiza Perez, Andrea Irene
Bal, Elisa Dora
Finkielsztein, Liliana Mónica
Callero, Mariana Alejandra

June 2018

Breast cancer is the first cause of cancer death in women. Many patients are resistant to current th...

Bp44mT: An orally active iron chelator of the thiosemicarbazone class with potent anti-tumour efficacy

Yu, Yu
Rahmanto, Y.
Richardson, D.

January 2012

Background and Purpose: Our previous studies demonstrated that a thiosemicarbazone iron chelator (di...

Novel thiosemicarbazone iron chelators induce up-regulation and phosphorylation of the metastasis suppressor N-myc down-stream regulated gene 1: A new strategy for the treatment of pancreatic cancer

Kovacevic, Zaklina
Chikhani, Sherin
Lovejoy, David B
Richardson, Des R

January 2011

Pancreatic cancer is an aggressive neoplasm, with a mortality rate close to 100%. The most successfu...

Identificazione dei targets cellulari e del meccanismo d'azione molecolare di complessi metallici di nuova sintesi

Montalbano, Serena

March 2019

The end goal of this project is the study of the biological activity of newly synthesized compounds,...

Synthesis Of Thiophene-thiosemicarbazone Derivatives And Evaluation Of Their In Vitro And In Vivo Antitumor Activities

de Oliveira
Jamerson Ferreira
Anekecia Lauro
Debora Barbosa
Cezar Augusto
Julia Furtado
Amelia Galdino
Ricardo Olimpio
Jorge Luiz
Ana Lucia
Joao Ernesto
Maria do Carmo

June 2016

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)A series of thiophene-2-thiosemi...

Anti-proliferative activity (IC<sub>50</sub> values) of the novel thiosemicarbazones in comparison to DFO and Dp44mT in several tumor cell-types and normal human dermal fibroblast (NHDF) cells.

Abstract

Extracted data

Anti-proliferative activity (IC<sub>50</sub> values) of the novel thiosemicarbazones in comparison to DFO and Dp44mT in several tumor cell-types and normal human dermal fibroblast (NHDF) cells.

Abstract

Extracted data

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