The impact of the interaction between <i>S. mansoni</i> and malaria on the effectiveness of ACT for reducing malaria prevalence and symptomatic malaria episodes.

<p>We compared (A) the proportional reduction of malaria prevalence with and without interaction and (B) the increase in symptomatic episodes of malaria due to elevated susceptibility to malaria mediated by <i>S. mansoni</i> infection. <i>S. mansoni</i> high worm burden was assumed to increase the risk of malaria infection by 85% , consistent with epidemiological studies <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0003234#pntd.0003234-Sokhna1" target="_blank">[6]</a>.