Model of LET-23 EGFR regulation by AGEF-1/Arf/AP-1 and LIN-2/7/10.

<p>(A) LET-23 EGFR is localized to both basal and apical membranes in the VPCs of wild-type animals. The LIN-2/7/10 complex promotes the basal localization while the AGEF-1/Arf/AP-1 ensemble either inhibits basal or promotes apical localization. (B) In an <i>agef-1(-)</i> background, there is more LET-23 EGFR on the basal and less apical. (C) In a <i>lin-2(-)</i> background, most all of the LET-23 EGFR is apical with presumably residue LET-23 EGFR at the basal membrane, but not enough to induce vulva cell fates. (D) In an <i>agef-1(-); lin-2(-)</i> background, the loss of AGEF-1 partially restores LET-23 EGFR to the basal membrane sufficient to induce vulva cell fates.