ABC transporter inhibitors increase PZQ-induced tegumental disruption in adult worms.

<p>Adult schistosomes were treated as in <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0003265#pntd-0003265-g001" target="_blank">Fig. 1</a>, and male worms analyzed by optical microscopy in an equivalent tegumental region just below the oral sucker. <b>A–D</b> show the overall region analyzed; <b>E–H</b> are zoomed images of equivalent regions of <b>A–D</b>, with damage more apparent. (<b>A, E</b>) 500 nM PZQ. (<b>B, F</b>) 500 nM PZQ+Combination A. (<b>C, G</b>) 500 nM PZQ+Combination B. (<b>D, H</b>) 500 nM PZQ+10 µM tariquidar.