Glomerular pathology of GN-model mice.

<p>(<b>a</b>) Glomerular histology of C57BL/6 control mice and early- and late-stage B6.MRLc1 GN-model mice. PAM staining (upper panels), PAS staining (lower panels). Bars = 20 µm. GN mice developed membranous and proliferative lesions. (<b>b</b>) Histological scores of glomerular area, glomerular cell number, and sclerosis score in glomerulus. Values = mean ± SE. A significant difference from the control value is indicated by *(<i>P</i><0.05) or **(<i>P</i><0.01). (<b>c</b>) Level of uACR. Values = mean ± SE. A significant difference from the control value is indicated by *(<i>P</i><0.05). (<b>d</b>) Early-stage glomerular ultrastructures of C57BL/6 control mice and B6.MRLc1 GN-model mice. Bars = 1 µm. Cap, capillary; Cl, capsular lumen; Pod, podocyte; GBM, glomerular basement membrane; Par, glomerular parietal epithelial cells. Arrowheads, podocyte foot process effacement. Asterisk, immune-complex deposition. Arrows, Bowman’s capsule.