Demographic and clinical profiles of patients with a Clinical Dementia Rating of 0.5 or more at baseline.

<p>Two-sample <i>t</i>-tests were used for group-wise comparisons of baseline scores and progression rates except for the UPDRS tremor/non-tremor scores. A two-way analysis of variance was used for the UPDRS tremor/non-tremor scores. No group-wise comparisons were performed for the backward digit-span owing to the small number of subjects. Data are given as the mean±SD except for the fields with asterisks. a and b indicate p<0.05 and p<0.01, respectively.</p><p>*Data are given as (the number of patients below −1 SD)/(the number of patients who underwent the test).</p>¶<p>The scores were calculated according to Lewis and colleagues. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0110547#pone.0110547-Lewis1" target="_blank">[5]</a> Data were obtained from 6 baseline memory-only and 6 baseline memory-plus patients.</p>†<p>The mean score of controls (n = 20, 65.5±4.8 years) is 21.3±3.5. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0110547#pone.0110547-Abe1" target="_blank">[49]</a>.</p>‡<p>The mean score of controls (n = 24, 66.1±5.3 years) is 32.9±4.4. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0110547#pone.0110547-Ishioka1" target="_blank">[32]</a>.</p>§<p>The mean score of controls (n = 20, 65.5±4.8 years) is 4.8±1.0. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0110547#pone.0110547-Abe1" target="_blank">[49]</a>; a statistical comparison was not performed owing to an insufficient number of subjects.</p><p>Abbreviations: UPDRS, Unified Parkinson's Disease Rating Scale; CDR, Clinical Dementia Rating; MMSE, Mini-Mental State Examination; ADAS, Alzheimer's Disease Assessment Scale; NE, not examined.</p><p>Demographic and clinical profiles of patients with a Clinical Dementia Rating of 0.5 or more at baseline.