Molecular controls of radiation-induced apoptosis in the neonatal rat kidney

The incidence of cell death due to radiation was examined in a neonatal in vivo model. Differences in the induction of apoptosis, amount of cell proliferation, S-phase cell death, Bcl-2 and p-53 expression could best be explained by the differences in the zonal state of differentiation and development. The present in vivo model may thus be useful in testing radiation therapies for renal cancer