Antiviral effects of lysosomotropic alkalinizing agents on the replication of avian and swine isolates.

<p>MDCK cells were treated as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0110631#pone-0110631-g001" target="_blank">Figure 1</a> with (A) amodiaquine, (B) chloroquine, (C) primaquine or (D) quinacrine and infected with 25 PFU of the H1N1 swine isolate A/Swine/OTH-33-2/2009 or the avian isolates H5N2 A/Emu/Texas/39924/1993, H5N1 A/Teal/Germany/WV632/2005, and H5N1 A/Domestic goose/Germany/R1400/2007. Viral plaques were counted and results are expressed as a percentage of plaque formation compared to its respective control i.e. untreated cells infected with the corresponding influenza strain (Plaque formation (%)). Results are representative of three to six independent experiments. Statistical significance: **p<0.01, ***p<0.001.