Sensitivity Analysis of Cycle-Specific Drug Effect Model.

<p>Simulated model profiles with changes in: A) Apoptosis duration, <i>T_A</i>, B) Maximum drug efficacy, <i>E_max</i>, and C) Drug potency, <i>EC₅₀</i>. D) Signature profile of cycle-specific drug mechanism model with dose escalation. Simulation were carried with parameters values of <i>T</i> = 1 day, <i>T_A</i> = 4 days, <i>p₀</i> = 2, <i>k_in0</i> = 0.05 g/day, <i>w_th</i> = 10 g, <i>E_max</i> = 1 and <i>EC₅₀</i> = 0.01 concentration, unless otherwise indicated. Arrows indicate dose administration at days 10, 20 and 30.