Selective blockade of stromal/parenchymal cell or BM/blood cell intrinsic NF-κB activity similarly inhibits BMDEPC recruitment.

<p>WT-GFP-BM, p50-GFP-BM and WT-NG-BM mice were injected with saline (Con) or LPS, and organs were harvested at 24 and 48 hours post-LPS. Cryosections were prepared and stained with GFP antibody and nuclei counterstained with DAPI. Number of GFP+ BMDEPCs on each slide from heart (<b>A</b>), lung (<b>B</b>), liver (<b>C</b>) and kidney (<b>D</b>) was counted, expressed as a percentage of total cells as revealed by DAPI nuclear staining, and compared between WT-GFP-BM and p50-GFP-BM, or WT-NG-BM mice. Mean ± SEM of 5 mice per group. <b>*</b>, p<0.05, compared with controls. #, p<0.05, compared with WT-GFP-BM mice at 24 or 48 hours. Blockade of intrinsic NF-κB activity in stromal/parenchymal cells (black bars) or in BM/blood cells (gray bars) similarly inhibits BMDEPC recruitment.