Tim-3 expression is inversely associated with NK cell activity.

<p>(A) The expression of Tim-3 and IFN-γ was analyzed in NK cells from septic mice at 24 h after LPS injection. The percentage of IFN-γ⁺ cells between Tim-3⁺ and Tim-3⁻ NK cell subsets was shown in the graphs. (B) Representative flow cytometry histograms of CD69 expression on NK cells from septic mice at 0, 12 and 24 h after LPS injection were shown. (C) The MFI of CD69 on NK cells was shown in the bar graphs. (D) The percentage of CD69⁺ NK cells between Tim-3⁺ and Tim-3⁻ NK cell subsets from septic mice at 24 h after LPS injection was shown. Data are mean ± SEM of at least three independent experiments. **<i>p</i><0.01, ***<i>p</i><0.001.