<p><b>A</b>. Load damping capacity in control (HIF-1α<sup>f/f</sup>) (a) and mutant (Foxa2<sup>iCre</sup>;HIF-1α<sup>f/f</sup>) (b) IVD at 4 months. <b>B</b>. Phase shift angle (a) and energy dissipation (b) based on the load damping test in control (HIF-1α<sup>f/f</sup>) and mutant (Foxa2<sup>iCre</sup>;HIF-1α<sup>f/f</sup>) IVD at 4 months. Statistical analysis performed between control and mutant groups: rmANOVA p<0.001 (a) and p<0.05 (b).</p
<p>(A, B) Testing of the DCA1 knockdown mutant showing <i>Tos17</i> insertion in the second intron o...
<p>(A) Immunohistochemical staining of Drosophila body wall muscles from transgenic larvae expressin...
<p>Change in folding energy (ΔΔG) of the <i>rplQ</i> mRNA for the five single-mutant strains generat...
<p><b>A</b>. H&E staining of NB (a,b), 1 month (c,d) and 4 months (e,f) NP in control (Foxa2<sup>iCr...
<p>(<b>A</b>) Principal component analysis and k-means clustering of tissues paced at 2 Hz on day 6 ...
<p>(A) Increased level of pMad at the NMJ synapses and in the motoneuron nuclei of <i>ube3a</i><sup>...
a<p>++: highly conserved; + conserved in vertebrates; − not conserved.</p>b<p>according to Palmai et...
<p><i><b>A–C,</b></i> FM 1-43 label of neuromast HCs in WT, <i>tm246a</i> and <i>t20325</i> mutants ...
<p><b>A</b>. H&E staining of E15.5 NP in control (Foxa2<sup>iCre</sup>;HIF-1α<sup>f/+</sup>) (a) and...
<p>(A). Phenotype of the anterior wing in wild-type and <i>mln</i> mutant. (B). Storage modulus (E′)...
<p>Fitness effects (top panel) are a property of the elasticity relationship between net protein fun...
<p>(<b>A</b>) C root mean square fluctuations of mutants compared to the wild-type. The values repor...
<p>Summary of the biophysical parameters of <i>Pf</i>MDH mutants, as assessed by Static Light Scatte...
<p>A) Age synchronised wild-type (+/+), <i>unc-112<sup>ts</sup></i> heterozygotes (+/−) and <i>unc-1...
<p><b>A,B</b>. Detection of fluorescence in frozen sections of NP isolated from E15.5 (A) and 1 mont...
<p>(A, B) Testing of the DCA1 knockdown mutant showing <i>Tos17</i> insertion in the second intron o...
<p>(A) Immunohistochemical staining of Drosophila body wall muscles from transgenic larvae expressin...
<p>Change in folding energy (ΔΔG) of the <i>rplQ</i> mRNA for the five single-mutant strains generat...
<p><b>A</b>. H&E staining of NB (a,b), 1 month (c,d) and 4 months (e,f) NP in control (Foxa2<sup>iCr...
<p>(<b>A</b>) Principal component analysis and k-means clustering of tissues paced at 2 Hz on day 6 ...
<p>(A) Increased level of pMad at the NMJ synapses and in the motoneuron nuclei of <i>ube3a</i><sup>...
a<p>++: highly conserved; + conserved in vertebrates; − not conserved.</p>b<p>according to Palmai et...
<p><i><b>A–C,</b></i> FM 1-43 label of neuromast HCs in WT, <i>tm246a</i> and <i>t20325</i> mutants ...
<p><b>A</b>. H&E staining of E15.5 NP in control (Foxa2<sup>iCre</sup>;HIF-1α<sup>f/+</sup>) (a) and...
<p>(A). Phenotype of the anterior wing in wild-type and <i>mln</i> mutant. (B). Storage modulus (E′)...
<p>Fitness effects (top panel) are a property of the elasticity relationship between net protein fun...
<p>(<b>A</b>) C root mean square fluctuations of mutants compared to the wild-type. The values repor...
<p>Summary of the biophysical parameters of <i>Pf</i>MDH mutants, as assessed by Static Light Scatte...
<p>A) Age synchronised wild-type (+/+), <i>unc-112<sup>ts</sup></i> heterozygotes (+/−) and <i>unc-1...
<p><b>A,B</b>. Detection of fluorescence in frozen sections of NP isolated from E15.5 (A) and 1 mont...
<p>(A, B) Testing of the DCA1 knockdown mutant showing <i>Tos17</i> insertion in the second intron o...
<p>(A) Immunohistochemical staining of Drosophila body wall muscles from transgenic larvae expressin...
<p>Change in folding energy (ΔΔG) of the <i>rplQ</i> mRNA for the five single-mutant strains generat...