Consequences of a pathological overexpression of HiF-1<i>α</i>.

<p>A. Accumulation of HiF-1<i>α</i> in mutated cells, compared to normal cells. The ratio [HiF-1<i>α</i>]/[HiF-1<i>α</i>] is plotted as a function of (HiF-1<i>α</i> synthesis rate) and (pVHL export rate). The black dotted square indicates the location of the peritoneal cancer studied by Yoshikawa et al. (2006) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0110495#pone.0110495-Yoshikawa1" target="_blank">[18]</a>, characterized by a 2-fold increase of HiF-1<i>α</i> protein and a 3-fold increase of HiF-1<i>α</i> mRNA. B. Effects of reoxygenation on normal cells, and mutated cells. Reoxygenation after hypoxia is simulated, and the evolutions of nuclear HiF-1<i>α</i> concentration are plotted in the case of normal ( = 1000, red curve), and mutated cells ( = 5000, black curve). The dotted lines represents the normoxic equilibrium levels in each case.