SCC lesions display both an increased CD4/CD8 ratio and an increased T-reg/CD8 ratio when compared with IEC lesions.

<p>Absolute CD3⁺CD4⁺ T-cell, CD3⁺CD4⁺FoxP3⁺ T-cell, and CD3⁺CD8⁺ T-cell numbers within each lesion were determined by flow cytometry and used to determine the proportion of (A) CD3⁺CD4⁺ T-cells to CD3⁺CD8⁺ T-cells (skin; n = 6, IEC; n = 9, SCC; n = 11), and (B) CD3⁺CD4⁺FoxP3⁺ T-cells to CD3⁺CD8⁺ T-cells (skin; n = 6, IEC; n = 7, SCC; n = 9). ns: not significant.