Activity of LQB-118 on golden hamsters infected with <i>L. braziliensis</i>.

<p>Golden hamsters (5/group) infected with <i>L. braziliensis</i> (10⁷) were treated on the seventh day of infection with LQB-118 intralesional (26 µg/kg/day) three times/week or orally (4,3 mg/kg/day) five times/week during eight weeks. Controls were untreated, treated with intralesional DMSO three times/week or Glucantime five times/week by intraperitoneal route. <b>A</b>) Lesion thickness was measured for nine weeks. The arrow indicates the start of treatment. Mean ± SD, # P<0.002 (in relation to untreated group). <b>*</b> p<0.001 (in relation to intralesional DMSO group); <b>B</b>) Intradermal reaction at <i>L. braziliensis</i> antigen was evaluated on the contralateral foot pad on eight week of infection. The swelling was measured 48 h later in the antigen-injected footpads. * p<0,04; ** p<0,01. Each point represents one animal and the horizontal bar indicates the mean. <b>C</b>) Parasite burden was assessment by limiting dilution at the end of treatment. *** p<0,001. il, intralesional/subcutaneous; ip, intraperitoneal.