Psychrophilins E–H and Versicotide C, Cyclic Peptides from the Marine-Derived Fungus <i>Aspergillus versicolor</i> ZLN-60

Four new cyclic peptides, psychrophilins E–H (<b>1</b>–<b>4</b>), possessing a rare amide linkage between the carboxylic acid in anthranilic acid (ATA) and the nitrogen from an indole moiety, along with a new ATA-containing hexapeptide, versicotide C (<b>5</b>), were obtained from the culture of the marine-derived fungus <i>Aspergillus versicolor</i> ZLN-60. The structures, including absolute configurations, were elucidated by a combination of HRESIMS, NMR, X-ray crystallography, TDDFT ECD calculations, and Marfey’s method. Versicotide C (<b>5</b>) is the first natural cyclic hexapeptide containing two anthranilic acids. Compounds <b>1</b>–<b>5</b> were not cytotoxic, and compound <b>3</b> showed potent lipid-lowering effects