<p>A) Left panel: evaluation of PTEN levels of expression in BCR-ABL-pcDNA3.1 transfected NIH3T3. Right panel: quantification of PTEN levels. B) PTEN mRNA levels in BCR-ABL transfected NIH3T3 cells. C) Left panel: PTEN levels by western immunoblot in primary CD34 positive cells obtained from the bone marrow of normal individuals and Chronic Myeloid Leukemia patients. Right panel: quantification of PTEN levels. D) Stably expressing pBabe-BCR-ABL infected NIH3T3 cells were treated with MG132 and UO126 for 8 hours. Control: parental NIH3T3 expressing pBABE-empty vector.</p
The Bcr-Abl fusion oncogene which resulted from a balanced reciprocal translocation between chromoso...
Chronic myeloid leukemia (CML) is caused by the BCR-ABL oncogene. The Philadelphia chromosome (Ph) f...
Objective: The t(9;22) translocation is associated with more than 95% of cases of chronic myeloid le...
<p>(<b>a</b>) BCR-ABL transcript expression was upregulated in all drug-resistant cells, whereas hig...
The tumor suppressor gene PTEN is inactivated in many human cancers. However, it is unknown whether ...
Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by the t(9;22) translo...
Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by the t(9;22) translo...
A small population of cancer stem cells named the ‘‘side population’ ’ (SP) has been demonstrated to...
<p>(<b>a</b>) Endogenous levels of <i>PTEN</i> mRNA in CML patients and normal donors were examined ...
A small population of cancer stem cells named the "side population" (SP) has been demonstrated to be...
A characteristic feature of chronic myeloid leukaemia (CML) is the inevitable advancement from a tre...
<p>The tumor suppressive function of PTEN is exerted within 2 different cellular compartments. In th...
The Bcr-Abl fusion oncogene which resulted from a balanced reciprocal translocation between chromoso...
The BCR/ABL chimeric protein plays a central role in the pathogenesis of chronic myelogenous leukemi...
Bcr-Abl is a constitutively active tyrosine kinase involved in the development and progression of ch...
The Bcr-Abl fusion oncogene which resulted from a balanced reciprocal translocation between chromoso...
Chronic myeloid leukemia (CML) is caused by the BCR-ABL oncogene. The Philadelphia chromosome (Ph) f...
Objective: The t(9;22) translocation is associated with more than 95% of cases of chronic myeloid le...
<p>(<b>a</b>) BCR-ABL transcript expression was upregulated in all drug-resistant cells, whereas hig...
The tumor suppressor gene PTEN is inactivated in many human cancers. However, it is unknown whether ...
Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by the t(9;22) translo...
Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by the t(9;22) translo...
A small population of cancer stem cells named the ‘‘side population’ ’ (SP) has been demonstrated to...
<p>(<b>a</b>) Endogenous levels of <i>PTEN</i> mRNA in CML patients and normal donors were examined ...
A small population of cancer stem cells named the "side population" (SP) has been demonstrated to be...
A characteristic feature of chronic myeloid leukaemia (CML) is the inevitable advancement from a tre...
<p>The tumor suppressive function of PTEN is exerted within 2 different cellular compartments. In th...
The Bcr-Abl fusion oncogene which resulted from a balanced reciprocal translocation between chromoso...
The BCR/ABL chimeric protein plays a central role in the pathogenesis of chronic myelogenous leukemi...
Bcr-Abl is a constitutively active tyrosine kinase involved in the development and progression of ch...
The Bcr-Abl fusion oncogene which resulted from a balanced reciprocal translocation between chromoso...
Chronic myeloid leukemia (CML) is caused by the BCR-ABL oncogene. The Philadelphia chromosome (Ph) f...
Objective: The t(9;22) translocation is associated with more than 95% of cases of chronic myeloid le...