Dynamin inhibition decreases apoE secretion from primary human macrophages.

<p>HMDM were incubated with indicated concentrations for 3 h (A and B) and for indicated time periods at 30 µM (C) with a representative compound for each class of dynamin inhibitor. MiTMAB (A–C), Dyngo-4a (E–F) and Dynole-34-2 (G–I). Cell viability and secreted apoE were measured by LDH assay and ELISA, respectively. (•) Ctrl and (▪) Treated. Data shown are mean ± SD from triplicate cultures representative of at least 3 individual donors. *<i>P</i><0.05 <i>v</i> Ctrl.