rs2282679 polymorphism association with diseases and traits that have been observationally related to vitamin D levels.

<p>Regression models were adjusted for age and sex. Analyses of disease-related traits were performed on both adult and youth CaMos cohorts; analyses of diseases were restricted to the CaMos adult cohort only. M-dashes indicate that summary data were not publically available.</p>∫<p>Measurement change for disease-related traits and OR for diseases. Change in measurement of disease-related trait is per each additional copy of the risk allele. All continuous variables were inspected for normality, and outliers (<1% of data points) were excluded. For diseases, ORs are reported per copy of risk allele. The null hypothesis is tested using α = 0.05. The Bonferroni method is used to maintain family-wise error rate when performing multiple testing through enforcing a more stringent α = 0.05/12 = 0.0042 (12 comparisons). Independence between outcomes was assumed in this correction.</p>∥<p>The natural logarithm was used.</p>¶<p>Effect estimates excluding participants with diabetes were similar for fasting glucose, −0.013 (95% CI −0.050, 0.023), <i>p</i> = 0.47, and for fasting insulin, −0.034 (95% CI −0.075, 0.007), <i>p</i> = 0.10.</p>*<p>ICBP had available GWAS data only on blood pressure measurements, not on hypertension; no association was found for systolic blood pressure, diastolic blood pressure, mean arterial pressure, and pulse pressure.</p>|<p>This effect estimate provided by METASTROKE is for overall ischemic stroke, which does not include TIA.</p><p>rs2282679 polymorphism association with diseases and traits that have been observationally related to vitamin D levels.