Anti-inflammatory protein treatment reduced TLR4 and MyD88 staining in mice after <i>P. gingivalis</i> infection + BA.

<p>(A) Immunohistochemical staining of TLR4 in sham-infected mice (left). (B) Increased TLR4 staining in mice infected with <i>P. gingivalis</i> + BA injury. (C) Increased MyD88 staining in mice infected with <i>P. gingivalis</i> + BA injury. (D) Decreased MyD88 staining in mice with <i>P. gingivalis</i> + BA after Serp-1 treatment. (E) Bar graph of MyD88 expression showing increased MyD88 in aortic adventitia in <i>P. gingivalis</i> infected mice + BA (24 weeks) compared to <i>P. gingivalis</i> + BA with Serp-1 (<i>P</i>≤0.056) or M-T7 treatment (<i>P</i>≤0.013). (F) Bar graph of TLR4 expression showing increased TLR4 in abdominal aortic adventitial in <i>P. gingivalis</i> + BA (24 weeks) compared to <i>P. gingivalis</i> + BA in Serp-1 (<i>P</i> = 0.0004) and in M-T7 treated mice (<i>P</i>≤0.0001).