<i>mef-2</i> mutations and increased calcium signaling suppress the starvation-induced downregulation of <i>srh-234</i> expression.

<p>A, C) Percentage of animals of the indicated genotypes expressing <i>srh-234</i>p::<i>gfp</i> at wild-type levels. Animals (n>150) were examined at 150× magnification for each genotype. B) Relative expression of <i>srh-234</i>p::<i>gfp</i> in <i>ocr-2</i> and <i>npr-1</i> mutants compared to wild-type. For strains carrying <i>ADL::egl-19(gf)</i> extrachromosomal arrays (see <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004707#s4" target="_blank">Material and Methods</a>), data shown is for two independent transgenic lines. Animals (n = 15–20) were examined at 400× magnification for each genotype. * and ** indicates values that are different from that of wild-type animals at <i>P</i><0.001, and <i>P</i><0.05, respectively, and # indicates the values that are different between the genotypes compared by brackets at <i>P</i><0.05 using either a two-sample <i>t</i>-test or a χ² test of independence. Error bars denote the SEP or SEM.