Anti-Tat IgG subclass profile before challenge and virological outcome.

<p>(<b>A</b>) The box-blot analysis represents the anti-Tat IgG and IgG subclass profile in plasma of cynomolgus macaques before (week 23) and after (week 44) the last Tat/Alum boost. For the anti-Tat IgG subclass profile, a cut off for each subclass was established based on the analyses of IgG subclasses in plasma of 30 naive cynomolgus macaques, as described in material and methods. (<b>B</b>) The rate of plasma viral load decline among vaccinees is indicated where the lines (dashed red lines for viremic; continous black lines for controllers) represent the mobile median starting from the first positive viremia sample during the acute phase of the infection. (<b>C</b>) The impact of anti-Tat IgG1 titers on the rate of vRNA decline during the post acute phase of the infection, as determined at week 44 during the immunization, is reported.