The number (<i>a</i>), cross-sectional area (<i>b</i>) and volume (<i>c</i>) of pulmonary metastases in PAI-1^−/− and wild-type mice fed the AIN93G or the high-fat diet.

<p>Two-way ANOVA and Tukey contrasts were performed to test for differences among the groups. Values (means ± SEM) with different superscripts are significantly different at <i>p</i>≤0.05 (n = 22 per group for PAI-1^−/− mice, n = 28 per group for wild-type mice). AIN WT: AIN93G-fed wild-type mice, AIN PAI-1^−/−: AIN93G-fed PAI-1^−/− mice, HF WT: high-fat fed wild-type mice, HF PAI-1^−/−: high-fat fed PAI-1^−/− mice.