Body weight.

<p>Two-way ANOVA and Tukey contrasts were performed to test for differences among the groups. The high-fat diet, compared to the AIN93G diet, increased body weights; the difference was significant starting 4 weeks after the initiation of experimental feeding (<i>p</i><0.01), and the significant increase continued throughout the experiment. Compared to wild-type mice, PAI-1 deficiency lowered body weights, and the difference was significant starting at week 6 of the experiment (<i>p</i>≤0.05). Values are means ± SEM (n = 11 per group for PAI-1^−/− mice, n = 14 per group for wild-type mice; second cohort). AIN WT: AIN93G-fed wild-type mice, AIN PAI-1^−/−: AIN93G-fed PAI-1^−/− mice, HF WT: high-fat fed wild-type mice, HF PAI-1^−/−: high-fat fed PAI-1^−/− mice.