Total exercise time for the animals that were implanted with a guide cannula in the VMH or in the peri-VMH area.

<p>Constant-speed running (20 m/min and 5% inclination) was performed at ambient temperatures of 25°C and 12°C (panel A). #<i>P</i><0.05 compared with the experimental trials at 25°C. The curves presented in the panel B show the maximum exercise duration tolerated by the rats subjected to the constant exercise sessions (panel B). The data are expressed as the number of rats that continued to run at specific time points at each ambient temperature.