CpT(ApG) depletion and CpG excess among large DNA viruses infecting invertebrate hosts.

<p>(a) Box plot showing the distribution of CpT(ApG) dinucleotides among large DNA viruses infecting invertebrate- and vertebrate hosts. The depletion of CpT(ApG) dinucleotides is more pronounced among large DNA viruses infecting invertebrates as compared to those infecting vertebrates (mean±SD: 0.72±0.10 vs 0.96±0.09; <i>P</i><0.0001). (b) Box plot showing the distribution of CpG dinucleotides among large DNA viruses infecting invertebrate- and vertebrate hosts. Large DNA viruses infecting invertebrates had a significantly higher CpG_O/E ratio than those infecting vertebrates (1.41±0.29 vs 0.99±0.26; <i>P</i><0.0001).