Microwave-Assisted Synthesis and Antifungal Activities of Polysubstituted Furo[3,2-c]chromen-4-ones and 7,8,9,10-Tetrahydro-6<i>H</i>-benzofuro[3,2-c]chromen-6-ones

<div><p></p><p>An efficient and novel microwave-assisted synthesis of furo[3,2-c]chromen-4-ones and 7,8,9,10-tetrahydro-6H-benzofuro[3,2-c]chromen-6-ones via 4-hydroxycoumarins with α-chloroketones or α-bromocyclohexanone in the presence of acetic acid (AcOH)/ammonium acetate (NH₄OAc) using DMF as solvent under microwave irradiation is described. Systematically, antifungal biological tests showed that most of the compounds exhibited potent antifungal activity against <i>Botrytis cinerea, Collecterichum capsica, Alternaria solani, Gibberella zeae</i>, and <i>Rhizoctorzia solani</i> at the concentration of 50 µg/mL. The corresponding EC50 values of these analogues have been detected, and compound <b>4i</b> showed better antifungal activity against tested fungi <i>Botrytis cinerea</i> and <i>Collecterichum capsica</i> than the reference Osthol.</p>