PPD inhibition of the growth of castration-resistant 22Rv1 xenograft tumors.

<p>22Rv1 cells were inoculated into castrated nude mice. When the tumors reached ∼100 mm³, the mice were treated with 40 mg/kg PPD through oral gavage 6 days per week (n = 11). <b>A.</b> Mean tumor volumes. <b>B.</b> Individual tumor weight at the conclusion of the experiment. <b>C.</b> Mean mouse body weights. <b>D.</b> Mean serum PSA level determined by ELISA, normalized by tumor weights, at the conclusion of the study. *, <i>P</i><0.05 from the control group. Error bars, SEM.