Anatomical distribution of ¹²⁵I-labelled BK- and JC-VLPs.

<p>Mice were injected intravenously with ¹²⁵I-labelled BK-VLPs (A) or JC-VLPs (B), euthanized after 10 min (black bars; n = 3) or 60 min (grey bars; n = 3 in A; n = 5 in B), and organs and tissues analyzed for radioactivity. The mice used in the circulatory half-life study (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0111762#pone-0111762-g002" target="_blank">Figure 2</a>) were included in this anatomical distribution study (60 min values). Total recovered radioactivity in all tissues at the given time points was taken as 100%. Error bars represent SEM. *Statistically significant difference (p<0.01) between tissue radioactivity at 10 min versus 60 min. # Brain radioactivity was measured at 60 min, only. GI tract, gastrointestinal tract (stomach and intestines including mesenterium).