Analysis of ASH1 and EZH2 methyltransferases protein expression with Slot Blot.
- Hussein Atta (656269)
- Mahmoud El-Rehany (656270)
- Olfat Hammam (557915)
- Hend Abdel-Ghany (656271)
- Maggie Ramzy (656272)
- Martin Roderfeld (389425)
- Elke Roeb (389426)
- Ayman Al-Hendy (330191)
- Salama Abdel Raheim (656273)
- Hatem Allam (656274)
- Heba Marey (656275)
Publication date
November 2014
DOIAbstract
<p>ASH1 (A, B) and EZH2 (C, D) protein expression were undetectable in the healthy livers. Both ASH1 and EZH2 protein expression markedly increased (p<0.01) following CCl<sub>4</sub> treatment for eight weeks. Treatment with HGF, mMMP-9 or combined HGF/mMMP-9 resulted in significant (p<0.01) reduction of both ASH1 and EZH2 protein expression in fibrotic livers. There was no significant difference in the ASH1 or EZH2 protein expression between the HGF-, mMMP-9-, or HGF/mMMP-9-treated fibrotic livers. (n = 6 per group).</p
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