The beneficial effects of pioglitazone on the survival of cardiac allografts were counteracted in T cell-PPARγ^ko.

<p>A. T cell-PPARγ^ko mice (ko) abrogate the protective effect of pioglitazone on the survival curve. B. iNOS, Arg1, and Mrc1 transcription levels in allografts were measured by RT-PCR 40 days after transplantation. The data are presented as the mean±SD for each group (n = 5), *p<0.05.