PPARγ-deficient T cells reduce survival and augment lesions associated with chronic rejection.

<p>A. The survival time of cardiac allografts in T cell-PPARγ^ko mice was significantly shorter than that of reduced compared with WT littermates. B. Cardiac allograft (bm12) sections of lesions 40 days after transplantation from T cell-PPARγ^ko mice (ko) or WT littermates. (a, b) HE staining, major view magnification 40×, left bottom view magnification 400×. Scale bars = 100 µm. (c, d) Masson trichrome staining, magnification 400×. T cell-PPARγ^ko mice exhibited severe lesions. Arrows indicate obvious intimal hyperplasia, asterisks indicate leukocytic infiltration, and filled arrowheads indicate collagen deposition. C. Graft coronary artery disease (GAD) and parenchymal rejection (PR) scores in T cell-PPARγ^ko mice were considerably increased compared with WT littermates. The data are presented as the mean±SD for each group (n = 8), *p<0.05.