The inferred demographic history of the Florida and Nebraska populations.

<p>Geographic location and photos of the derived light and ancestral dark mouse populations from (A) Florida (photos by J. Miller and S. Carey) and (B) Nebraska (photos by C. Linnen) (top panel). Cartoon representation of the inferred demographic model of the two species (middle panel). Both models include selection acting on the bottlenecked population (with effective population size reduced to <i>fN</i>_e, where <i>N</i>_e is the ancestral population size) immediately after the divergence from the ancestral population at time <i>d</i>, and the selected allele becomes fixed at time <i>τ</i>. Likelihood ratio (LR) profile of Sweepfinder in both populations of light-colored mice (bottom panel), where the horizontal line indicates the significance cutoff. Stars indicate the approximate location of causal mutations conferring light pigmentation. Because there are multiple <i>Agouti</i> alleles, we here polarize (into “light” or “dark” class) based on the SNP mostly strongly associated with pigment variation (as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0110579#pone.0110579-Linnen2" target="_blank">[26]</a>).