Cumulative distributions of site dN/dS values of the viral proteins.

<p>D-value, with p-value, represents the deviation of the New World curve from the Old World curve. D-value was calculated by the two-sample Kolmogorov test. Averaged site dN/dS is displayed on the top left, which reflects the overall selection pressure on the protein. A) MP. B) NSP. C) The emergence of putative tyrosine phosphorylation site in the New World MP. Consensus sequence pictures were created using Weblogo <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0111957#pone.0111957-Crooks1" target="_blank">[34]</a>. Searching is based on PROSITE database <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0111957#pone.0111957-Sigrist1" target="_blank">[35]</a>. PROSITE ID of the tyrosine phosphorylation site is PS00007 where its consensus is [RK]-x(2,3)-[DE]-x(2,3)-Y. D) Codon alignment of the homologous region of the site.