Evaluation of kSORT to predict acute rejection in 191 serially collected samples.

<p>191 blood samples serially collected within 6 mo before (pre) or after (post) biopsy-confirmed AR were evaluated by kSORT. Frequencies of samples predicted as AR (red) or predicted as No-AR (green) were compared between sample collection time points (>3 mo prior to AR biopsy, <i>n</i> = 30; 0–3 mo prior to AR biopsy, <i>n</i> = 35; at AR biopsy, <i>n</i> = 74; 0–3 mo after AR biopsy, <i>n</i> = 31; >3 mo after AR biopsy, <i>n</i> = 21; and at No-AR/stable time points, <i>n</i> = 216). 62.86% of samples collected 0–3 mo (1.15±0.90 mo) prior to the AR biopsy had high probabilities for AR predicted by kSORT (96.36±0.08). High probabilities for AR persisted in 51.6% of samples collected 0–3 mo post-AR (94.60%±0.14); in comparison, 83.8% of the No-AR samples were always predicted as No-AR (8.20%±0.12). Mean AR scores were significantly different between pre-AR samples (0–3 mo) and No-AR/stable samples, as well as between AR samples and No-AR/stable samples.