Proposed diagram of <i>p,p′</i>-DDE-induced colorectal adenocarcinoma cell proliferation.

<p>At low concentrations, <i>p,p′</i>-DDE promotes colorectal adenocarcinoma cell proliferation through c-Myc and cyclin D1 overexpression resulted from the stimulation of Wnt/β-catenin and Hedgehog/Gli1 signalings, which were mediated by oxidative stress.