Validation of the best-fit crosslinker parameter values.

<p>(A) Shear modulus of simulation results (Sim) using the best-fit crosslinker parameter values and elastic modulus (G′) in shear experiments (Exp) from Stein et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0111896#pone.0111896-Stein1" target="_blank">[30]</a>. 5 independent runs were simulated for seven different collagen densities (1, 1.5, …, 4 mg/ml using a 0.5 mg/ml increment). (B) Tensile modulus of various strain rate experiments, experiments from Provenzano et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0111896#pone.0111896-Provenzano3" target="_blank">[41]</a>, Roeder et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0111896#pone.0111896-Roeder1" target="_blank">[40]</a>, Riching et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0111896#pone.0111896-Riching1" target="_blank">[24]</a>, Lopez-Garcia et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0111896#pone.0111896-LopezGarcia1" target="_blank">[42]</a>, predicted values (Pre) using a power-law fitting from Lopez-Garcia et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0111896#pone.0111896-LopezGarcia1" target="_blank">[42]</a>, and simulation results using the best-fit crosslinker parameter values. Inset figure is magnified view of our experimental data of 2 mg/ml collagen gels at very slow train rate of 0.046/min.