Longitudinal fat-suppressed imaging of dystrophic <i>mdx</i> leg muscles.

<p>A) Representative fat-suppressed images of leg muscle from the left hindlimb of one <i>mdx</i> (top) and one wild-type (bottom) mouse over time, each imaged from 6 to 12 weeks of age. Black arrows mark a region of muscle that showed a reduction in intensity between time points, while gray arrows mark a region that showed an increased intensity between time points. The tibia is present as a triangular structure in the upper right corner of the leg sections. B) The percentage of tissue within the leg that has an elevated signal intensity shows a difference between <i>mdx</i> and wild-type mice at all time points and illustrates a change between the peak disease (6 week) and recovery phases of <i>mdx</i> disease (n = 5 wild-type and 6 <i>mdx</i> mice; data are means ±SEM; *<i>p</i><0.05, **<i>p</i><0.01, ***<i>p</i><0.001).