<p>Histopathologic analyses of multiple mouse tissues. <b>A</b>. A hemangioma (asterisk, right panel) found in the uterus of a <i>NIAM<sup>m/m</sup></i> mouse compared to normal uterine tissue (left panel). (H&E, 100x) <b>B</b>. Pulmonary papillary adenoma in a homozygous <i>NIAM<sup>m/m</sup></i> mouse (arrow, right panel). A depiction of normal lung tissue from a control mouse is shown (left panel). (H&E, 20x) <b>C</b>. Harderian gland adenoma of a <i>NIAM<sup>m/m</sup></i> mouse (asterisks, right panel). A representative image of a normal Harderian gland (asterisk) from a control mouse is depicted (left panel). (H&E, 40x) <b>D</b>. A representative image of a normal liver from a control mouse (left panel) versus a focus of cellular alter...
Rapid advances in generating new mouse genetic models for lung neoplasia provide a continuous challe...
<p><b>A</b>. Normal spleen from a control mouse. <b>B</b>. Severe lymphoid depletion and reduction o...
<p>WT, wild-type mice; +/m, heterozygous mutator mice. (A) Gross necropsy of euthanized moribund mic...
<p><b>A</b>. Weights of spleens from +/+ and +/m mice (CON, n = 15) compared to <i>NIAM<sup>m/m</sup...
<p>*, p<0.0025 by Fisher's Exact Test between control (<i>NIAM<sup>+/+</sup></i> and <i>NIAM<sup>+/m...
Nuclear Interactor of ARF and Mdm2 (NIAM, gene designation Tbrg1) is a largely unstudied inhibitor o...
<p>Development of foci of cellular alteration (FCA), the proliferating cell nuclear antigen (PCNA)-l...
<div><p>Nuclear Interactor of ARF and Mdm2 (NIAM, gene designation <i>Tbrg1</i>) is a largely unstud...
Nuclear Interactor of ARF and Mdm2 (NIAM, gene designation Tbrg1) is a largely unstudied inhibitor o...
<p>A) Adenocarcinoma with solid patterns and squamous metaplasia in a <i>FVB-Met<sup>M1248T/L1193V</...
The mouse is the most commonly used animal for modelling human disease. New approaches for generatin...
<p>(A and B) Hematoxylin and eosin staining of uterine sections from <i>Hand2<sup>f/f</sup></i> (A) ...
<p>4–5 animals examined per group. All selected mutant mice are at end of life, wild type mice are a...
<p>(A) VCP<sup>R155H/R155H</sup> mice are much smaller and weaker and demonstrate gross abnormalitie...
<p>(<b>A</b>) Histological staining with H&E of tumors grown following the injection of 1 spheroid o...
Rapid advances in generating new mouse genetic models for lung neoplasia provide a continuous challe...
<p><b>A</b>. Normal spleen from a control mouse. <b>B</b>. Severe lymphoid depletion and reduction o...
<p>WT, wild-type mice; +/m, heterozygous mutator mice. (A) Gross necropsy of euthanized moribund mic...
<p><b>A</b>. Weights of spleens from +/+ and +/m mice (CON, n = 15) compared to <i>NIAM<sup>m/m</sup...
<p>*, p<0.0025 by Fisher's Exact Test between control (<i>NIAM<sup>+/+</sup></i> and <i>NIAM<sup>+/m...
Nuclear Interactor of ARF and Mdm2 (NIAM, gene designation Tbrg1) is a largely unstudied inhibitor o...
<p>Development of foci of cellular alteration (FCA), the proliferating cell nuclear antigen (PCNA)-l...
<div><p>Nuclear Interactor of ARF and Mdm2 (NIAM, gene designation <i>Tbrg1</i>) is a largely unstud...
Nuclear Interactor of ARF and Mdm2 (NIAM, gene designation Tbrg1) is a largely unstudied inhibitor o...
<p>A) Adenocarcinoma with solid patterns and squamous metaplasia in a <i>FVB-Met<sup>M1248T/L1193V</...
The mouse is the most commonly used animal for modelling human disease. New approaches for generatin...
<p>(A and B) Hematoxylin and eosin staining of uterine sections from <i>Hand2<sup>f/f</sup></i> (A) ...
<p>4–5 animals examined per group. All selected mutant mice are at end of life, wild type mice are a...
<p>(A) VCP<sup>R155H/R155H</sup> mice are much smaller and weaker and demonstrate gross abnormalitie...
<p>(<b>A</b>) Histological staining with H&E of tumors grown following the injection of 1 spheroid o...
Rapid advances in generating new mouse genetic models for lung neoplasia provide a continuous challe...
<p><b>A</b>. Normal spleen from a control mouse. <b>B</b>. Severe lymphoid depletion and reduction o...
<p>WT, wild-type mice; +/m, heterozygous mutator mice. (A) Gross necropsy of euthanized moribund mic...