Vaccine-induced antibody responses.

<p>Antibodies reactive against (A) the ecto-domain of the WNV E protein, and (B) inactivated WNV were measured in the individual animals at indicated time points. Humoral responses were quantified as sample:negative ratio (S/N). Vaccine-induced neutralizing capacity (PRNT50) of macaque sera was determined using the plaque reduction neutralization test (C). Individual animals are depicted as dots: group 1 (red), group 2 (green), and group 3 (blue). The median value is indicated for each group. Unpaired t-test was used to compare the responses between the groups. Statistical significant differences were defined as p<0.05 and are indicated with arches in the figure.