Effect of REGN1035 and/or anti-VEGF (sunitinib or ziv-aflibercept) on (A, B) RP-R-01 and (C) RP-R-02 tumor vasculature.

<p>Tumors from treated mice were harvested, processed, and tissue sections were stained for the differential expression of CD31 (red) for visualization of endothelial cells (left panels). (D, E, F) Blinded quantitative analysis of CD31 (right panels). Results are expressed as mean percentage positive stained area ± S.E. *<i>p</i><0.05 using adjusted t-test analysis.