Litter sizes, maternal, placental and fetal weights, and placental/fetal weight ratios.

<p>Controls (n = 17) and msFlt-1(1-3)-treated mice (n = 6) had a litter size consistent with the strain average published by the vendor (n = 11.5). The number of pups (13.8±0.4, p = 0.046) and living pups (13.6±0.45, p = 0.05) were higher in hsFlt-1-e15a-treated mice (n = 18) than in controls. The total weight of living pups (14.2±0.56 g, p = 0.04) and maternal weights (56.3±1.1 g, p = 0.04) were also higher in hsFlt-1-e15a-treated mice than in controls. Truncated msFlt-1(1-3)-treated mice did not differ in any parameters from the controls. Among hsFlt-1-e15a-treated mice, the total weights of living pups was higher in the Ad-RGD-CYP-hsFlt-1-e15a treated mice than in controls (15±0.48 g, p = 0.043). The number of pups (14.3±0.42, p = 0.047) and the number of living pups (14.1±0.46, p = 0.039) was higher in the Ad-RGD-CMV-hsFlt-1-e15a treated mice than in controls. Stars denote statistical significance.