Effects of SIH and its analogs on iron-induced oxidation of ascorbic acid in a buffered solution (pH 7.4).

<p>Chelators were assayed at iron binding equivalents (IBE) of 0.1 (excess of Fe), 1 (iron-chelator complexes with a fully filled coordination sphere) and 3 (excess of free chelator). DFO and EDTA were used as negative and positive control chelators, respectively. The results are expressed as a percentage of the control group in the absence of chelator (100%). Results are Mean ±SD (<i>n</i>≥3 experiments). Statistical significance (ANOVA): * <i>p</i><0.05, ** <i>p</i><0.01, *** <i>p</i><0.001 as compared to the control group (iron with ascorbate).