Gene and protein structures of mouse DSPP and DMP-1.

<p>(A) SIBLING location. SIBLING proteins were located next to each other on human chromosome 4 and mouse chromosome 5. (B) The amino acids sequences of PP (the carboxyl-terminal region of DSPP) and C-DMP1 (the carboxyl-terminal region of DMP-1). The SSD repeats are colored green and the RGD domains are colored red. The amino acids are numbered from the amino-terminal of DSPP and DMP-1 after signal peptide removal. (C) The exon-intron and protein structures of mouse DSPP and DMP-1. Two glycosaminoglycans (GAG) sites have been reported in mouse DSPP (serine242 and serine254) and one GAG site in DMP1 (serine 89). SSD repeats; Serine–serine–aspartic acid repeat sequence. RGD; Arg-Gly-Asp integrin-binding site.