Differential Stimulation of Insulin Secretion by GLP-1 and Kisspeptin-10 - Figure 1

<p><b>A</b>. Percent of insulin content secreted from intact islets after static incubation at 2.8, 10, or 16.7 mM glucose with and without KP (1 µM, dark gray) or GLP-1 (20 nM, light gray). Secretion from untreated control islets is shown in white. Data are the mean ± S.E. <i>n</i> = 4–19. *(<i>p</i><0.05) and **(<i>p</i><0.001) indicate significance compared to untreated control. <b>B</b>, Glucose-dependent percent change in NAD(P)H from untreated intact islets (circles) and islets treated with KP (1 µM, squares) or GLP-1 (20 nM, triangles) compared to values at 2 mM glucose. Data are the mean ± S.E. <i>n</i> = 9–11. *<i>p</i><0.01.