Effects of exposure to either TT2238- or CC2238/αANP on viability and oxidative stress in CASMCs.

<p>A. Cell vitality as determined by trypan blue (n = 4); B. Cell vitality as assessed by FACS (n = 4): representative scatter plots are shown with percentages of live cells (bottom left), early apoptotic cells (upper left), late apoptotic cells (upper right), necrotic cells (bottom right); C. ROS levels (n = 6); D. NADPH and eNOS expression levels (n = 3). Representative western blots are shown; bars represent results of densitometric analysis. Control (CTR): untreated cells; positive control: cells treated with H₂O₂.♦p<0.01; for all other comparisons p<0.0001.